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Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May doi: What did this study do? What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib.
Rofecoxib has been withdrawn from the market due to safety concerns. It also significantly improved physical function. Paracetamol at any dose, including the maximum daily dose, did not have a clinically meaningful effect on osteoarthritis pain.
No results were given for adverse effects. What does current guidance say on this issue? What are the implications? Retraction and republication on 8th July Explanation can be found here. Commentaries Expert commentary This review indicates a need to reduce our reliance on paracetamol and effective non-steroidal anti-inflammatory drugs NSAIDs as symptomatic treatment for osteoarthritis.
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Cox-2 inhibitors are no more effective than traditional NSAIDs and have no tangible advantages in terms of gastrointestinal tolerability. In contrast, they expose patients to an increased risk of cardiovascular adverse effects. Etoricoxib was no more effective than other NSAIDs such as ibuprofen, naproxen or diclofenac in these situations. If you think you have experienced side effects from this medicine you can report them using the yellow card scheme. You should check with your pharmacist before taking any new medicines while you're taking etoricoxib, to make sure that the combination is safe.
It's fine to take paracetamol with Arcoxia. You can also take opioid-type painkillers such as codeine, co-codamol, tramadol or morphine in combination with Arcoxia. However, don't take anti-inflammatory painkillers NSAIDs like aspirin, ibuprofen or naproxen with Arcoxia, as this increases the risk of getting side effects on the gut. Remember that many cold and flu remedies and over-the-counter painkillers contain ibuprofen or aspirin and so should be avoided while you're taking etoricoxib.
Be sure to check the ingredients of other medicines before taking them with Arcoxia, or ask your pharmacist for advice. It's also best to check with your pharmacist if you want to use an anti-inflammatory gel such as diclofenac, ibuprofen, ketoprofen or piroxicam while you're taking Arcoxia, because this may not be safe for everyone. If you're taking a medicine that affects blood clotting, such as those below, taking Arcoxia may increase the risk of bleeding, particularly in the gut:.
You are more at risk of ulceration or bleeding in your gut if you take etoricoxib with steroids such as prednisolone. Etoricoxib may oppose the effect of diuretics and medicines for high blood pressure antihypertensives. There may be an increased risk of side effects on the kidneys if etoricoxib is taken with any of the following medicines. If you're taking one of these with Arcoxia your doctor may want to monitor your kidney function:. Read more detailed information about medicines that interaction with etoricoxib here.
Parenting Mental health Healthy eating Conditions Follow. Type keyword s to search. Science Photo Library Getty Images. What is Arcoxia? Arcoxia tablets contain etoricoxib, which is an anti-inflammatory medicine. Arcoxia etoricoxib is only available on prescription. What is Arcoxia used for? How does Arcoxia etoricoxib work? Who should not take Arcoxia? Arcoxia tablets are not suitable for: Children under 16 years of age.
People allergic to any ingredient of the tablets. People who have ever had an allergic reaction after taking aspirin or other NSAIDs such as ibuprofen or naproxen for example an asthma attack, itchy rash, nasal inflammation rhinitis or swelling of the lips, tongue and throat.
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