To learn more about Healthwise, visit Healthwise. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Updated visitor guidelines. You are here Home » Creatinine and Creatinine Clearance. Top of the page. Creatinine and Creatinine Clearance. Test Overview Creatinine and creatinine clearance tests measure the level of the waste product creatinine say "kree-AT-uh-neen" in your blood and urine.
Three types of tests can be done. Blood creatinine level The blood creatinine level shows how well your kidneys are working. Creatinine clearance A creatinine clearance test measures how well creatinine is removed from your blood by your kidneys. Blood urea nitrogen-to-creatinine ratio This test measures the amount of urea in your blood. To find out if your kidney disease is changing. To see how well the kidneys work in people who take medicines that can cause kidney damage.
To check for severe dehydration. Dehydration generally causes BUN levels to rise more than creatinine levels. This causes a high BUN-to-creatinine ratio.
Kidney disease or blocked urine flow from your kidney causes both BUN and creatinine levels to rise. How To Prepare You may be asked to: Not do any strenuous exercise for 2 days 48 hours before having the tests.
Not eat more than 8 ounces of meat, especially beef, or other protein for 24 hours before the blood creatinine test and during the creatinine clearance urine test. Drink plenty of fluids if you are asked to collect your urine for 24 hours. But don't drink coffee or tea.
These are diuretics that cause your body to pass more urine than normal. How It Is Done Blood tests A health professional uses a needle to take a blood sample, usually from the arm. Timed urine test You collect your urine for a period of time, such as over 4 or 24 hours. When you first get up, you empty your bladder.
But don't save this urine. Write down the time you began. For the set period of time, collect all your urine. Don't get toilet paper, pubic hair, stool feces , menstrual blood, or anything else in the urine sample.
Keep the collected urine in the refrigerator for the collection time. Empty your bladder for the last time at or just before the end of the collection period. Add this urine to the large container. Then write down the time. How long the test takes The urine test will take 24 hours. The blood test will take a few minutes.
How It Feels Blood test When a blood sample is taken, you may feel nothing at all from the needle. Urine test This test usually doesn't cause any pain or discomfort. Other sources in the patient sample such as ascorbic acid, acetone, or cephalosporins may erroneously produce an orange-red color as they react with the picric acid. The chemical method is time consuming and not widely used in automated instruments.
Creatinine may be also measured enzymatically. Multiple enzymatic methods utilizing creatiniase have been used to measure creatinine. BUN is most frequently measured using enzymatic methods. The first step involves the enzyme urease to hydrolyze urea, thereby producing ammonium. The second step involves the quantitative measurement of ammonium using a variety of methods to determine the amount of urea in the sample.
Tietz Fundamentals of Clinical Chemistry. Philadelphia, PA : Saunders ; Google Scholar. Google Preview. Price C Finney H. Developments in the assessment of glomerular filtration rate. Clinica Chimica Acta. Measurement of residual glomerular filtration rate in the patient receiving repetitive hemodialysis. Kidney Int. A method for estimating nitrogen intake of patients with chronic renal failure. Cystatin C: an improved estimator of glomerular filtration rate? Clin Chem. Fawcett J Scott E.
A rapid and precise method for the determination of urea. J Clin Path. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.
Sign In or Create an Account. Sign In. Advanced Search. Creatinine formation and formula. Creatinine source and formation. Creatinine clearance from the blood. Possible References Used. Comments Hellen mumba Reply.
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