It is probably the most used drug in all of anesthesia. Every day essentially, when patients go under general anesthesia that whole state is a reversible coma.
It's a difference in dosage. How does a medically-induced coma differ from a natural coma? The body doesn't usually decide to enter a coma. A coma is a profound shutdown of brain function. It typically results from profound trauma, brain injury, a drug overdose, stroke—some very gross insult. There isn't a natural analogue for [a medically induced coma].
Are there after effects? It's hard to sort out, because if you're going to these extremes you're already dealing with a very dire situation. If there are effects later on, it's an extremely difficult distinction to make whether it is an effect of the drug-induced coma.
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Comments 0. It is important for medical doctors to have ways of knowing which coma patients are likely to awake. In most hospitals, there are clinical tests to find out which coma patients are not doing well.
But there are very few tests to predict when a patient will awake, and an accurate prediction is usually challenging. In our study, we aimed at developing a test that predicts whether a patient will awake from a coma. For this test, we studied the brain responses of coma patients to sounds [ 4 ]. Imagine, for example, a series of sounds coming from tapping your fingers repeatedly, or from playing a musical note on the piano.
Imagine listening to the same note being played over and over again. You can also hear some of these sounds in Audio File 1. We presented these sounds to the patients and while we measured their brain activity with EEG. Our goal was to study how their brains reacted to the series of sounds. Different colors on the maps show that different brain regions were activated in response to sounds. Brain functions can be different from one patient to another.
For this reason, we computed a mathematical model to find patterns in brain responses to standard or deviant sounds Figure 1B. We repeated this analysis two times, in the first and second day of coma. The first time we measured, the body temperature of the patients was lowered. The second time, the temperature was back to normal [ 5 ]. All the patients we included in this study were fully unconscious. Their bodies could not react to most of the things happening around them.
What about their brains?
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